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Aprepitant

Aprepitant

Synonym

5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluorophenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one  

CAS #

170729-80-3

Molecular Formula

C23H21F7N4O3

Molecular Weight

534.43

Structure

CAS 170729-80-3

Product Introduction

Aprepitant, with CAS 170729-80-3, is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists (SPA).

Aprepitant (CAS 170729-80-3) is effective in helping to prevent CINV because it antagonizes the NK1 receptor. This receptor is located at the brain stem nuclei of the dorsal vagal complex and is a crucial part of the regulation of vomiting.

This is due to the receptor binding with substance P. Aprepitant (CAS 170729-80-3) can be used to treat acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.